Search results for: 'spike lentivirus'

Lentiviruses for SARS-CoV-2 Research To understand the mechanism of SARS-CoV-2 cell entry, it is essential to study how Spike proteins interact with the ACE2 receptor. However, such studies are hampered by the danger of producing and manipulating live coronavirus. A safer alternative to using live coronavirus is to use recombinant lentivirus pseudotyped with the coronavirus S protein. The Spike pseudotyped lentivirus includes a luciferase reporter, allowing the monitoring of viral entry into...

Viral Tools Frequently Asked Questions FAQ Topic: -Any- General Lentiviruses AAVs FAQ Search: How should I store the viral particles (lentivirus, AAV or VSV) that I just rec...

Custom Lentivirus Services BPS Bioscience has developed a diverse portfolio of lentivirus products to study COVID-19 , cell signaling pathways , CAR T-cell therapy , CRISPR , and immunotherapy . In addition to our product portfolio , we also offer custom services to develop a lentivirus suited for your research needs.  Customizable Options Reporters ( GFP , Luciferase , Dual Reporter ) Antibiotic selection markers ( Puromycin , Hygromycin , G4...

Lentiviruses Lentiviral transduction is a powerful tool for introducing genes into cells and is used extensively for cellular engineering. It has recently made its way to the clinic with ex-vivo cell therapy applications. Lentiviruses (LV) have also been used extensively for the modeling of SARS-CoV-2 viral infection of human cells. Lentiviral transduction is a powerful tool for introducing genes into cells and is used extensively for cellular engineering...

Coronavirus Services Biochemical Screening Cell-Based Services Cell Lines /CRISPR Protein Binding Studies/BLI BPS Bioscience has developed innovative proteins , cell lines , lentiviruses , and assay kits , to enable a wide range of preclinical activities for investigating potential COVID-19 antiviral drugs. These kits and services aim to rapidly advance drugs into the clinic by screening for compounds that prevent the ...

SARS-CoV-2 Coronavirus Variants The COVID-19 pandemic, caused by the novel  SARS-CoV-2 coronavirus , has ravaged the globe, infecting over 450 million people and causing over 6 million deaths as of early 2022. The recent emergence of new SARS-CoV-2 variants is a severe concern, especially omicron and delta variants, as many of these mutations occur within the Spike protein and appear to increase transmissibility and infectivity. The graphics belo...

Virus-Based Tools Virus-based tools such as Lentivirus, Adeno-Associated Virus (AAV), and Vesicular Stomatitis Virus (VSV) are critical for cell engineering and the study of viral infection.  We have designed a suite of ready-to-use viral reagents to address a wide span of research areas including virology (particularly Coronaviruses), immunotherapy, CAR-T therapy, CRISPR, cell signaling, and more.        Lentiviruses Ideal for pseudotyp...

SARS-CoV-2 Antibody Detection SARS-CoV-2 has spread across the globe effectively at a rapid pace causing a worldwide pandemic. Infection with this highly contagious respiratory virus can be asymptomatic or present as COVID-19, a disease with varying degrees of severity. Clinical symptoms may include fever, dry cough, anosmia, gastrointestinal symptoms, hypercoagulability, hyperimmune response (cytokine storm), and acute respiratory distress syndrome (ARDS) with disease progression (1). Patie...

SARS-CoV-2 Coronavirus & COVID-19 There are seven known human coronaviruses , including the novel SARS-CoV-2. Four of these strains cause only mild respiratory symptoms; however, coronaviruses became notorious after outbreaks of Severe Acute Respiratory Syndrome (SARS) in 2002 and Middle East Respiratory Syndrome (MERS) in 2012. The SARS-CoV-2 (2019-nCoV) coronavirus, first identified in late 2019, causes severe pneumonia and respiratory infection (COVID-19).  The S...

Frequently Asked Questions BPS Bioscience is here to answer your questions and provide project guidance. On the following pages, we outline some of the most frequently asked questions separated by product type. If your question is not answered through these resources, please contact us today and we are happy to assist.  Proteins Cell Lines Assay Kits ...

Citations   This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.  Search By Product Name or Catalog Number Name Title 10X HAT Assay Buffer (50095...

Technical Notes and Application Notes Immunotherapy | Cancer Targets | CAR-T/NK Cell Therapy | Gene & Cell Therapy | Cell Culture | RNA Editing | Cancer Pathways | CRISPR/Cas9 | Cell Receptor Targets | Ubiquitination | Protein Conjugation | Technology | Cholesterol Pathways | SARS-CoV-2/COVID-19 Immunotherapy TL1A:DR3 - A Pathway for Immunomodulation Therapeutic Targeting of TSLP in Asthma and COPD A2aR & Im...

Proteases as Targets for SARS-CoV-2 Treatment Researchers have shown that proteases are actively used by SARS-CoV-2 for it’s entry and replication into human cells. To support research on this topic, BPS Bioscience provides a range of screening kits to identify inhibitory compounds directed against these human and viral proteases. SARS-CoV-2’s mechanism of entry and replication into human cells is now well known and described by the scientific community. The penetration steps can be d...