KRAS Screening & Profiling Services
KRAS is an important protein in the RAS/MAPK signaling pathway that transmits signals from activated cell surface receptors leading to cell proliferation and survival. KRAS function is controlled by cycling through an inactive, GDP-bound state and an active, GTP-bound state. Activation of KRAS occurs when it binds to Guanine Nucleotide Exchange Factor (GEF) proteins, including SOS, which initiate the exchange of GDP for ...
Emerging Therapeutic Approaches Against RAS Cancer Mutations
Introduction
RAS (rat sarcoma virus) proteins are small GTPases involved in signal transduction as part of the RAS/MAPK (mitogen-activated protein kinase) pathway and are involved in cell proliferation and differentiation. There are three human RAS genes: KRAS (Kristen rat sarcoma virus), HRAS (Harvey rat sarcoma virus) and NRAS (neuroblastoma rat sarcoma virus). The KRAS gene encodes two isoforms, KRAS-4B and KRAS-4A, but due t...
Protein Frequently Asked Questions
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How do I thaw recombinant proteins?
Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening the tube. Avoid multiple freeze/thaw cycles. Enzymes are particularly sensitive to freeze/thaw and may lose some activity if thawed again. When proteins are diluted to perform an assay do not freeze and re-use the diluted protein.
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Screening and Profiling Services
Evaluate lead compounds with our biochemical and cell-based screening services to identify specific inhibitors or activators. Save time by letting us screen your small molecules or biologics of interest against our unique assay panels or determine IC 50 values. With our portfolio of > 600 assays available as a service, we’re here to help advance your drug discovery program.
Our biochemical-based inhibitor...
Small Molecule Cancer Therapy Targets
For some cancers, small molecules that disrupt, inhibit, or agonize target protein function may be the best therapeutic option. Indeed, many new targeted therapeutics are now approved together with companion diagnostics to identify patient populations most likely to benefit from the new treatment.
For some cancers, small molecules that disrupt, inhibit, or agonize target protein function may be the best therapeutic...
Bioactive Proteins & Enzymes
BPS Bioscience specializes in manufacturing bioactive enzymes and protein complexes, offering over 2000 protein products critical for drug discovery. We feature a large selection of epigenetic and metabolic enzymes, kinases and other cell signaling proteins, as well as cancer-related proteins and their mutants, including KRAS, PARP proteins, and immune checkpoint molecules. Contact us to learn how our products and services can help you reach your resea...
Frequently Asked Questions
BPS Bioscience is here to answer your questions and provide project guidance. On the following pages, we outline some of the most frequently asked questions separated by product type. If your question is not answered through these resources, please contact us today and we are happy to assist.
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IgG Antibodies and Fcγ Receptors in Immunotherapy
IgG Antibodies and Fcγ Receptors in Immunotherapy
Monoclonal, immunoglobulin G (IgG), antibodies are the basis of powerful therapies for treating cancer, viral infections, and autoimmune disease. The power of therapeutic antibodies comes from their ability to bind antigen targets with high specificity and then harness the functions of the larger the immune system. There are a variety of immune responses. Cytotoxic anti...
Citations
This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.
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10X HAT Assay Buffer (50095...
