Primary Cells
To support innovation across Immunology and other research areas, BPS Bioscience offers negatively selected, highly enriched CD4+ and CD8+ T cells, and ready-to-use Chimeric Antigen Receptor (CAR)-T cells such as anti-CD19 CAR, anti-BCMA CAR, and control T cells. Primary CAR-T cells, produced by high-titer lentiviral transduction of human primary CD4+ and CD8+ T cells, are used as a positive control in CAR-T cytotoxicity assays, in the design...
Targeted Protein Degradation Approaches and Applications
Introduction
Traditional approaches to regulate protein activity have relied on direct protein interactions by using inhibitors or ligands. However, these target only about 10% of the known 4000 disease-linked proteins, with many being considered “undruggable” due to their quaternary structure. In recent years new strategies to target “undruggable” proteins have been developed, harnessing the power of the cells’ own protei...
