Search results for: 'ace2 cell line'

Coronavirus Services Biochemical Screening Cell-Based Services Cell Lines /CRISPR Protein Binding Studies/BLI BPS Bioscience has developed innovative proteins , cell lines , lentiviruses , and assay kits , to enable a wide range of preclinical activities for investigating potential COVID-19 antiviral drugs. These kits and services aim to rapidly advance drugs into the clinic by screening for compounds that prevent the ...

Lentiviruses Lentiviral transduction is a powerful tool for introducing genes into cells and is used extensively for cellular engineering. It has recently made its way to the clinic with ex-vivo cell therapy applications. Lentiviruses (LV) have also been used extensively for the modeling of SARS-CoV-2 viral infection of human cells. Lentiviral transduction is a powerful tool for introducing genes into cells and is used extensively for cellular engineering...

Lentiviruses for SARS-CoV-2 Research To understand the mechanism of SARS-CoV-2 cell entry, it is essential to study how Spike proteins interact with the ACE2 receptor. However, such studies are hampered by the danger of producing and manipulating live coronavirus. A safer alternative to using live coronavirus is to use recombinant lentivirus pseudotyped with the coronavirus S protein. The Spike pseudotyped lentivirus includes a luciferase reporter, allowing the monitoring of viral entry into...

Viral Tools Frequently Asked Questions FAQ Topic: -Any- General Lentiviruses AAVs FAQ Search: How should I store the viral particles (lentivirus, AAV or VSV) that I just rec...

SARS-CoV-2 Coronavirus & COVID-19 There are seven known human coronaviruses , including the novel SARS-CoV-2. Four of these strains cause only mild respiratory symptoms; however, coronaviruses became notorious after outbreaks of Severe Acute Respiratory Syndrome (SARS) in 2002 and Middle East Respiratory Syndrome (MERS) in 2012. The SARS-CoV-2 (2019-nCoV) coronavirus, first identified in late 2019, causes severe pneumonia and respiratory infection (COVID-19).  The S...

Frequently Asked Questions BPS Bioscience is here to answer your questions and provide project guidance. On the following pages, we outline some of the most frequently asked questions separated by product type. If your question is not answered through these resources, please contact us today and we are happy to assist.  Proteins Cell Lines Assay Kits ...

Citations   This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.  Search By Product Name or Catalog Number Name Title 10X HAT Assay Buffer (50095...

Protease Screening & Profiling Proteases are catalytic enzymes found in all forms of life, including viruses, that regulate a wide range of vital physiological processes. In animals, they are critical for digestion of food, lysosome and proteasome degradation, apoptosis, blood coagulation, cell cycle regulation, cell signaling, and more. The dysregulation of protease activity can lead to pathologies such as arthritis and inflammatory diseases, cardiovascul...

VSV Tools VSV (Vesicular stomatitis virus) is an enveloped, negative-stranded RNA virus with a simple structure. Its ability to infect a wide range of mammalian cell types has made VSV a valuable tool to study virus entry, replication, and assembly. The glycoprotein of VSV (termed VSV-G), which binds to the LDL-receptor (low-density lipoprotein receptor), is responsible for the attachment and entry of VSV into a susceptible host cell. The VSV-G glycoprotein can be deleted from the VSV (V...

Screening and Profiling Services Evaluate lead compounds with our biochemical and cell-based screening services to identify specific inhibitors or activators. Save time by letting us screen your small molecules or biologics of interest against our unique assay panels or determine IC 50 values. With our portfolio of > 600 assays available as a service, we’re here to help advance your drug discovery program. Our biochemical-based inhibitor...