Coronavirus Services
Biochemical Screening
Cell-Based Services
Cell Lines /CRISPR
Protein Binding Studies/BLI
BPS Bioscience has developed innovative proteins , cell lines , lentiviruses , and assay kits , to enable a wide range of preclinical activities for investigating potential COVID-19 antiviral drugs. These kits and services aim to rapidly advance drugs into the clinic by screening for compounds that prevent the ...
Protein Binding Studies / BLI Detection Services
Bio-Layer Interferometry (BLI) is a powerful analytical technique for studying biomolecular interactions. BLI measures changes in interference patterns of light reflected from a biosensor tip, which is typically coated with a layer of molecules relevant to the study. As biomolecules bind to or dissociate from the biosensor surface, the interference patterns change, providing real-time data on the kinetics and affinity of these int...
SARS-CoV-2 Variants: Evading the Immune System
The COVID-19 pandemic, caused by the novel SARS-CoV-2 coronavirus , has ravaged the globe, infecting over 145 million people and causing over 3 million deaths as of the time of this article. Ending the pandemic will require a combination of effective interventions, including therapeutics, diagnostics, and vaccines. Several monoclonal antibody therapeutics have received emergency use authorization, and a number of vaccines have been devel...
SARS-CoV-2 Antibody Detection
SARS-CoV-2 has spread across the globe effectively at a rapid pace causing a worldwide pandemic. Infection with this highly contagious respiratory virus can be asymptomatic or present as COVID-19, a disease with varying degrees of severity. Clinical symptoms may include fever, dry cough, anosmia, gastrointestinal symptoms, hypercoagulability, hyperimmune response (cytokine storm), and acute respiratory distress syndrome (ARDS) with disease progression (1). Patie...
SARS-CoV-2 Coronavirus & COVID-19
There are seven known human coronaviruses , including the novel SARS-CoV-2. Four of these strains cause only mild respiratory symptoms; however, coronaviruses became notorious after outbreaks of Severe Acute Respiratory Syndrome (SARS) in 2002 and Middle East Respiratory Syndrome (MERS) in 2012. The SARS-CoV-2 (2019-nCoV) coronavirus, first identified in late 2019, causes severe pneumonia and respiratory infection (COVID-19).
The S...
Citations
This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.
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10X HAT Assay Buffer (50095...
SARS-CoV-2 Coronavirus Variants
The COVID-19 pandemic, caused by the novel SARS-CoV-2
coronavirus , has ravaged the globe, infecting over 450 million people and causing over 6 million deaths as
of early 2022. The recent emergence of new SARS-CoV-2 variants is a severe concern, especially omicron and delta
variants, as many of these mutations occur within the Spike protein and appear to increase transmissibility and
infectivity. The graphics belo...
Proteases as Targets for SARS-CoV-2 Treatment
Researchers have shown that proteases are actively used by SARS-CoV-2 for it’s entry and replication into human cells. To support research on this topic, BPS Bioscience provides a range of screening kits to identify inhibitory compounds directed against these human and viral proteases.
SARS-CoV-2’s mechanism of entry and replication into human cells is now well known and described by the scientific community. The penetration steps can be d...
Lentiviruses for SARS-CoV-2 Research
To understand the mechanism of SARS-CoV-2 cell entry, it is essential to study how Spike proteins interact with the ACE2 receptor. However, such studies are hampered by the danger of producing and manipulating live coronavirus. A safer alternative to using live coronavirus is to use recombinant lentivirus pseudotyped with the coronavirus S protein. The Spike pseudotyped lentivirus includes a luciferase reporter, allowing the monitoring of viral entry into...
