Cell Cytotoxicity Screening & Profiling Services
Small Molecule Cell Cytotoxicity Assays
Understanding cell cytotoxicity, either as a result of targeted therapy or as a side effect, is important in drug development. Our expert scientists can help determine effective dose curves for your molecules of interest in whole cell assays, whether they are small molecules or biologics, including antibody drug conjugates. Over 30 different tumor cell lines are availabl...
The Promise of NK Cell Therapeutics
Introduction
NK cells are the first line of defense against cancer and have been in the spotlight as a cancer therapy in the last decade. Their advantages versus T cells, such as their safety profile and not requiring MHC (Major Histocompatibility Complex)-antigen stimulation to become cytotoxic, have made NK cells attractive. However, as with T cells, the TME (tumor microenvironment) can suppress their activity, and infiltration into solid tumors is s...
CD19 Research Products
CD19, a cell surface protein specific to B cells, has emerged as an effective immunotherapy target to treat B cell malignancies and autoimmune diseases.
By leveraging monoclonal antibodies, chimeric antigen receptor (CAR) T cells and NK cells, or bispecific T cell/NK cell engagers (BiTEs/BiKEs), CD19-directed immunotherapies aim to selectively eliminate CD19-expressing cells. In cancer, these ther...
Natural Killer Cells
Natural Killer (NK) cells are lymphocytes involved in the innate immune system that respond to infected cells and tumor cells, limiting these pathologies. They are now considered potential tools for adoptive cell therapies.
Natural Killer (NK) cells are lymphocytes involved in the innate immune system that respond to infected cells and tumor cells, limiting these pathologies. They are now considered potential tools for adoptive cel...
Primary Cells
To support innovation across Immunology and other research areas, BPS Bioscience offers negatively selected, highly enriched CD4+ and CD8+ T cells, and ready-to-use Chimeric Antigen Receptor (CAR)-T cells such as anti-CD19 CAR, anti-BCMA CAR, and control T cells. Primary CAR-T cells, produced by high-titer lentiviral transduction of human primary CD4+ and CD8+ T cells, are used as a positive control in CAR-T cytotoxicity assays, in the design...
