Search results for: 'PCSK9'

PCSK9 Screening & Profiling Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a critical regulator of cholesterol metabolism through its interaction with the hepatic LDL receptor (LDLR). PCSK9 is an endopeptidase that binds to the EGFR-like domain of LDLR, leading to LDLR degradation, which in turn, results in increased circulating LDL. Inhibiting the PCSK9-LDLR interaction is an increasingly desirable therapeutic approach for lowering LDL-cholest...

PCSK9 Assay Service

Cholesterol & the PCSK9 Pathway Role & Significance Cholesterol is an important molecule for normal cell function, and serves as a precursor for steroid hormones and bile acids.  Reducing LDL-C levels, most commonly by statins, has been shown to substantially reduce CVD events. However, statin therapy alone is not adequate to lower LDL-C for many patients, especially those with familial hypercholesterolemia. LDL receptors (LDLRs) play a key role in regulating ...

TR-FRET Assays Simplify and Accelerate Drug Discovery Introduction Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) is a powerful technique commonly used to analyze the binding of two interacting molecules. Since most biological responses involve an interaction between at least two partners, TR-FRET is well suited to study a wide range of events, including many that characterize cellular signaling pathways. Possible applications are limitless: interaction ...

Metabolic Enzyme Screening & Profiling Metabolic enzymes that regulate cellular energy pathways are essential for life. This includes all the processes required for material circulation and energy exchange, including catabolism and anabolism of nucleotides, sugars, proteins, and lipids. Metabolic pathway abnormalities have been correlated with diseases, such as diabetes and cancer, and are under investigation for targeted therapeutics. We ...

Technical Notes and Application Notes Immunotherapy | Cancer Targets | CAR-T/NK Cell Therapy | Gene & Cell Therapy | Cell Culture | RNA Editing | Cancer Pathways | CRISPR/Cas9 | Cell Receptor Targets | Ubiquitination | Protein Conjugation | Technology | Cholesterol Pathways | SARS-CoV-2/COVID-19 Immunotherapy OX40 Signaling and Its Implications for Immunotherapy TL1A:DR3 - A Pathway for Immunomodulation Therape...

Protein Binding Studies / BLI Detection Services Bio-Layer Interferometry (BLI) is a powerful analytical technique for studying biomolecular interactions. BLI measures changes in interference patterns of light reflected from a biosensor tip, which is typically coated with a layer of molecules relevant to the study. As biomolecules bind to or dissociate from the biosensor surface, the interference patterns change, providing real-time data on the kinetics and affinity of these int...

Screening and Profiling Services Evaluate lead compounds with our biochemical and cell-based screening services to identify specific inhibitors or activators. Save time by letting us screen your small molecules or biologics of interest against our unique assay panels or determine IC 50 values. With our portfolio of > 600 assays available as a service, we’re here to help advance your drug discovery program. Our biochemical-based inhibitor...

Citations   This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.  Search By Product Name or Catalog Number Name Title 10X HAT Assay Buffer (50095...