Native Nucleosome (HeLa-derived)

Catalog #

52039

$695 *

Size: 0.6 mg

Qty

Bulk/Custom

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Description

Nucleosomes prepared from mammalian HeLa cells (depleted from Histone H1) as a substrate for histone methyltransferase assays.

This product has been cited 9 times.

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Product Info

Storage and Usage

Citations9

Species

Human

Host Species/Expression System

HeLa

Purity

≥90%

Format

Aqueous buffer solution

Formulation

20 mM Tris-HCl, pH 7.5, 1 mM EDTA, 3 mM DTT, 10 mM Na butyrate, and 20% glycerol

Background

Nucleosomes are portions of DNA that are wrapped around histone proteins in the form of a histone octamer. The histone octamer consists of two copies of H2A, H2B, H3 and H4. Nucleosomes correspond to subunits of chromatin and allow the DNA to be compacted enough to fit into the cell’s nucleus. The presence of nucleosomes at specific points of the genome determines the ability of regulatory proteins to access DNA.

References

1. Meagher, R.B., Mussar, K.J., Epigenetics Chromatin 2012 Jul 20;5(1):11.
2. Huang, H., et al., Biosystems 2012 Aug;109(2):214-9.

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Datasheets/Protocols

52039 Lot 240205-A

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Native Nucleosome (HeLa-derived)

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