Bortezomib

Catalog #

27028

$150 *

Size: 10 mg

Qty

Bulk/Custom

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Description

Potent (Ki, 0.6 nM), specific and reversible proteasome inhibitor; no significant inhibitory activity against other enzymes or receptors. Bortezomib inhibits cell proliferation of H460 cells (human non-small cell lung cancer cell lines) with an IC50 of 0.1 µM and has been associated with suppresion of prostate cancer cell lines with an IC90 of 10 nM.

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Synonyms

Velcade, MG-341, PS-341

Product Info

Storage and Usage

Citations

Purity

≥99%

Format

White to off-white solid.

Formula

C₁₉H₂₅BN₄O₄

384.2 Da

Solubility

Soluble in DMSO at 200 mg/ml; soluble in ethanol at 200 mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.

CAS Registry #

179324-69-7

References

1. Bouchard, PR., et al. 55th Annual Meeting of the American College of Veterinary Pathologists (ACVP) & 39th Annual Meeting of the American Society of Clinical Pathology (ASVCP), ACVP and ASVCP (Eds.) (2004).
2. Ling, Y., et al. Clin. Cancer Res. 9: 1145-1154 (2003).
3. Williams, S., et al. Mol. Cancer Ther. 2: 835-843 (2003).

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