Aminophylline

Catalog #

27731

$200 *

Size: 25 mg

Qty

Bulk/Custom

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Description

Aminophylline is a non-selective phosphodiesterase (PDE) inhibitor with an IC50 of 0.12 mM. Inhibition of PDE prevents the breakdown of secondary messenger molecules cAMP and cGMP, which play a vital role in signal transduction.

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Synonyms

theophylline ethylenediamine; bis(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione); ethane-1,2-diamine

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Product Data Gallery

Product Info

Storage and Usage

Citations

Format

white to off-white powder

Target(s)

PDE

Formula

C₁₆H₂₄N₁₀O₄

420.4 Da

Solubility

Soluble in water (3.7 mg/ml). Solutions should be freshly prepared. Not soluble in alcohols.

CAS Registry #

317-34-0

Background

Aminophylline is a bronchodilator that is used together with other medicines to treat the acute symptoms of asthma, bronchitis, emphysema, and other lung diseases. Aminophylline is also a competitive adenosine receptor antagonist and it is thought to have potential therapeutic value for cardiac ischemia.

References

1. Crisanti, et al., Am. J. Physiol. 277, R829-R835, (1999).
2. Chanda, et al., Pol. J. Pharmacol. 50, 80-82, (1998).
3. Thakker, et al. Analytical Profiles of Drug Substances 2nd ed., (1982) 2, 1-44.

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Aminophylline

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