Epacadostat (INCB024360)
Catalog #
27339-2
$690
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Description
Epacadostat (INCB024360) is an orally available hydroxyamidine and inhibitor of indoleamine 2,3- dioxygenase (IDO1), with an IC50 of 10 nM. It shows little activity against other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). Epacadostat displays potential immunomodulating and antineoplastic activities.
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Synonyms
INCB024360, INCB24360, IDO inhibitor
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Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
≥98%
Format
White powder
Formula
C11H13BrFN7O4S
MW
438.2 Da
Solubility
Soluble in DMSO.
Biological Activity
Epacadostat has been reported to restore and increase the proliferation of
various immune cells including dendritic cells, NK cells, and T cells in vitro and in vivo.
CAS Registry #
1204669-58-8
References
1. Koblish, HK., et al., Molec. Cancer Therapeutics. 2010; 9: 489-498.
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