14-3-3 zeta Protein, His-tag (Human) Recombinant
Catalog #
79039
$395
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Description
Human 14-3-3 zeta Protein, GenBank Accession No. NM_012479, full length, with N-terminal His-tag, expressed in Sf9 insect cells using baculovirus. MW = 31 kDa.
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Synonyms
14-3-3 zeta, YWHAZ, KCIP-1, MGC111427, MGC126532, MGC138156
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Product Data Gallery
4-20% SDS-PAGE Coomassie Staining
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
Sf9
Purity
≥90%
Format
Aqueous buffer solution
Formulation
50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol
MW
31 kDa
Amino Acids
14-3-3 zeta (His-Full Length)
Genbank #
NM_003406
UniProt #
P63104
Background
14-3-3 zeta (also known as tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 zeta protein plays a key role in cancer biology by being an important regulator of major cellular processes such as proliferation, differentiation, senescence and apoptosis (1). 14-3-3 zeta protein has been shown to interact with the IRS1 protein, suggesting a role for this protein in regulating insulin sensitivity by interrupting the association between the insulin receptor and IRS1 (2).
References
1. Li, Z. et al: Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation. Proc Natl Acad Sci U S A. 2008; 105(1):162-7.
2. Niemantsverdriet, M. et al: Cellular functions of 14-3-3 zeta in apoptosis and cell adhesion emphasize its oncogenic character. Oncogene. 2008;27(9):1315-9. 2007.
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