Vinpocetine

Catalog #

27778-1

$140 *

Size: 100 mg

Qty

Bulk/Custom

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Description

Vinpocetine, also known as Cavinton or ethyl apovincaminate, is a specific inhibitor of basal and calmodulin-activated PDE1. Also blocks voltage-gated Na+ channels.

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Synonyms

Cavinton; ethyl apovincaminate; Vinpocetin;

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Product Info

Storage and Usage

Citations

Format

white solid

Target(s)

PDE1

Formula

C₂₂H₂₆N₂O₂

350.5 Da

Solubility

Soluble in ethanol up to 50 mM or DMSO at 5 mg/ml

Biological Activity

Vinpocetine is selective for PDE1: IC50 = 21 µM, vs. PDE3: IC50 = 300 µM (bovine heart). Vinpocetine inhibits differently the various subtypes of PDE1 (IC50 from 8 to 50 µm). It is also reported to inhibit PDE7B with an IC50 of 60 µM, and it can have effects on Heat Shock Factor 1 (EC5050 = 195 µM) and ADH-induced lipid peroxidation ( IC50 = 137 µM in rat brain microsome).

CAS Registry #

42971-09-5

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Vinpocetine

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