S- (+)-Rolipram

Catalog #

27648-3

$410 *

Size: 50 mg

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Description

S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 µM. It has anti-inflammatory and anti-depressant activity in the central nervous system.

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Synonyms

(4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one

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Product Info

Storage and Usage

Citations

Target(s)

PDE4B

Formula

C₁₆H₂₁NO₃

275.3 Da

CAS Registry #

85416-73-5

Background

Rolipram is a racemic drug that increases brain cAMP availability by inhibiting phosphodiesterase. The S-(+)-Rolipram enantiomer is 2-10x less potent than the R-(-)-Rolipram compound. PDE4B is involved in dopamine-associated and stress-related behaviours, and is believed to be the PDE4 subtype involved in the antipsychotic effects of PDE4 inhibitors such as rolipram.

References

1. Schneider et al (1986). Eur.J.Pharmacol. 127 105.
2. Owens et al (1997). Biochem.J. 326 53.
3. Ohsawa et al (1998). Jpn.J.Pharmacol. 77 147.

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S- (+)-Rolipram

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