Novo-TRX

Catalog #

27500

$335 *

Size: 20 µl

Qty

Bulk/Custom

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*US Pricing only. For international pricing, please contact your local distributor.

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Description

Novobiocin is an aminocoumarin antibiotic that is produced by Streptomyces niveus. Along with other aminocoumarin antibiotics, novobiocin is a very potent inhibitor of bacterial DNA gyrase. It works by targeting the GyrB subunit of the enzyme involved in energy transduction. Novo-TRX is Texas Red-labeled novobiocin, which can be used as a fluorescence probe in assays for screening DNA gyrase inhibitors.

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Product Info

Storage and Usage

Citations

Purity

≥93.3% by HPLC

Supplied As

10 µM solution in anhydrous DMSO

Format

A red aqueous solution

Formula

C₇₀H₈₀N₆O₁₈S₂

1357.5 Da

Biological Activity

Novo-TRX has been shown to inhibit bacterial DNA gyrase activity with an IC50 of 0.6 =uM.

CAS Registry #

1476-53-5 (Novobiocin, sodium salt)

References

1. Lamour V, et al., J Biol Chem. 2002 May 24;277(21):18947-53.
2. Glaser BT, et al., J Biomol Screen. 2011 Feb;16(2):230-8.

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