Human Parathyroid Hormone Recombinant

Catalog #

90231-B

$205 *

Size: 100 µg

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Description

Recombinant Human PTH-84 is a disulfide-linked homodimeric protein consisting of 84 amino acid residues, and migrates as an approximately 9 kDa under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human PTH mature chain was expressed in E. coli.

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Synonyms

PTH, Parathyroid hormone, Parathyrin

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥95% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from a 0.2 µm filtered phosphate buffer solution, pH 7.

9 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

32–115

Biological Activity

The activity was determined by the dose-dependent proliferation of human UMR106 cells and was found to be 1 x 10⁴ IU/mg.

Genbank #

P01270

UniProt #

P01270

Background

Parathyroid hormone is a circulating hormone that acts as the central regulator of calcium metabolism by directly targeting bone, kidney, and intestine. The classical concept of PTH action is that it regulates serum calcium levels by stimulating bone resorption, however, intermittent administration of PTH selectively stimulates bone formation. It is now known that PTH binds to its receptor PTH1R, and activates the G protein α subunits.Besides PKA and PKC activation, PTH also regulates MAPKs including p42/p44 ERKs, p38, and c-Jun N-terminal kinase subtypes.

References

1. Esbrit P, Alcaraz MJ. Biochem Pharmacol. 2013 May 15,85(10):1417-23.
2. Bellido T, et al. Bone. 2013 Jun,54(2):250-7.

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Human Parathyroid Hormone Recombinant

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