Human Neurotrophin-3 Recombinant

Catalog #

90225-B

$205 *

Size: 10 µg

Qty

Bulk/Custom

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Synonyms

NT3, Neurotrophin 3, NT-3, NGF-2, Nerve Growth Factor 2, NTF3

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥97% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from a 0.2 µm filtered PBS solution, pH 7.5.

14 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

139–257

Biological Activity

The ED₅₀ was determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 10-50 ng/ml.

Genbank #

P20783

UniProt #

P20783

Background

NT-3 is found in neurons of the central nervous system. NT-3 is expressed also in muscles and its expression is down-regulated in denervated muscles. Many human gliomas express and secrete NT-3 into the conditioned medium. Some protein domains of NT-3 are identical with those of NGF and BDNF. NT-3 selectively supports the survival of neuronal cell populations, and prevents the death of cultured embryonic rat spinal motor neurons at picomolar concentrations. NT-3 has been shown to enhance sprouting of corticospinal tract during development and after adult spinal cord lesion. The activities of NT-3 and BDNF are additive in some systems. The biological activities of NT- 3 are mediated by a receptor belonging to the trk family of receptors with intrinsic tyrosine-specific protein kinase activity. NT-3 only binds weakly to the trk receptor which is a high-affinity receptor for NGF.

References

1. J. Immunol., Apr 2009, 182: 4705 - 4712.
2. J. Neurosci., Jan 2009, 29: 575 - 587.
3. J. Cell Biol., Dec 2006, 175: 1029 - 1042.

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Human Neurotrophin-3 Recombinant

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