Human Neuregulin 1 beta Recombinant

Catalog #

90224-B

$205 *

Size: 50 µg

Qty

Bulk/Custom

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*US Pricing only. For international pricing, please contact your local distributor.

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Synonyms

NRG1B, NRG-1beta, Neuregulin 1, MSTP131, HGL, Glial Growth Factor, GGF1, Heregulin, Alpha, NDF, Neu Differentiation FactorHRG

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥96% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from a 0.2 µm filtered 10 mM phosphate buffer, pH 7.0, containing 2% mannitol, 0.5% HSA.

7 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

177–237

Biological Activity

The ED₅₀ was determined by the dose-dependent proliferation of human MCF-7 cells was found to be <0.3ng/ml, corresponding to a specific activity of 2x 10⁶ Units/mg.

Genbank #

Q02297

UniProt #

Q02297

Background

Neuregulins (NDF, heregulin, GGF ARIA, or SMDF) are EGF-like growth and differentiation factors that signal through tyrosine kinase receptors of the ErbB family. The ErbB2 and ErbB4 receptors cooperate in transmission of neuregulin-1 signals in the heart, whereas ErbB2 and ErbB3 cooperate in neural crest cells.

References

1. Circulation, Jul 2009, 120: 310 - 317.
2. J. Neurosci., Jun 2009, 29: 7667 - 7678.
3. Invest. Ophthalmol. Vis. Sci., Apr 2009, 50: 2075.

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Human Neuregulin 1 beta Recombinant

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