Human MCP-4(CCL13) Recombinant

Catalog #

90214-B

$205 *

Size: 25 µg

Qty

Bulk/Custom

Add to Favorites

*US Pricing only. For international pricing, please contact your local distributor.

●

Purchase

●

Description

Recombinant MCP-4 is a disulfide-linked monomeric protein consisting of 76 amino acid residues and migrates as an approximately 9 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human MCP-4 (CCL13) mature chain was expressed in E. coli.

●

Synonyms

MCP-4, CCL13, Chemokine (C-C Motif) Ligand 13, Monocyte Chemoattractant Protein 4, CKb10, NCC1, SCYA13, NCC-1, MCP4

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥98% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from a 0.2 µm filtered 20 mM Phosphate buffer, 100 mM NaCl, pH 7.5.

9 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

24–108

Biological Activity

Determined by its ability to chemoattract human monocytes using a concentration range of 20.0-40.0 ng/ml.

Genbank #

Q99616

UniProt #

Q99616

Background

Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is member of a distinct, structurally-related subclass of CC chemokines. MCP-4/CCL13 is a major chemoattractants for eosinophils, basophils monocytes and T-lymphocytes. The MCP protein family bind to specific G-protein-coupled receptors, initiating a signal cascade within the cell. Expression of MCP-4/CCL13 mRNA and protein is greater in the sputum, epithelium, submucosal inflammatory cells and bronchoalveolar lavage fluid of asthmatics than in healthy individuals. Involvement of MCPs has also been demonstrated in renal inflammation and atopic dermatitis and the expression of this protein is also correlated with enhanced inflammatory immune responses during immunotherapy.

References

1. Rheumatology, Apr 2006, 45: 421 - 424.
2. Am J Physiol Lung Cell Mol Physiol, Nov 2001, 281: 1288.
3. Am. J. Respir. Crit. Care Med., Aug 2000, 162: 723 - 732.

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Human MCP-4(CCL13) Recombinant

PRODUCTS

SERVICES

RESOURCES

COMPANY