Human Interleukin-31 Recombinant

Catalog #

90190-A

$130 *

Size: 2 µg

Qty

Bulk/Custom

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Description

Recombinant Interleukin-31 is a disulfide-linked monomer protein consisting of 142 amino acid residues, and migrates as an approximately 18 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-31 mature chain was expressed in E. coli.

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Synonyms

IL-31, interleukin 31 , IL31

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥95% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from a 0.2 µm filtered PBS solution, pH 7.5.

18 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

24–164

Biological Activity

The ED₅₀ was determined by the ability to induce STAT3 activation in U87MG cells, and was determined to be ≥ 7 ng/ml.

Genbank #

Q6EBC2

UniProt #

Q6EBC2

Background

IL-31 is a recently discovered helical cytokine, belonging to the gp130/IL-6 cytokine family.The receptors for IL- 6 family are type I receptors, and they share a number of common structural motifs, such as the cytokine-binding domain with two pairs of conserved cysteine residues and a WSXWS sequence motif in the extracellular domain. IL-31 is expressed preferentially by activated Th2 CD4+ T cells, signaling through a heterodimeric receptor complex composed of IL-31RA and OSMR. Recent studies in both humans and mice have suggested a link between IL- 31/IL-31R expression and skin inflammation although the functional significance of endogenous IL-31/IL-31R interactions in influencing innate and adaptive immune responses remains unknown.

References

1. J. Immunol., May 2009, 182: 6088 - 6094.
2. Invest. Ophthalmol. Vis. Sci., Apr 2008, 49: 2531.
3. J. Exp. Med., Mar 2007, 204: 481 - 487.

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Human Interleukin-31 Recombinant

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