Human Interleukin-29 Recombinant
Catalog #
90187-A
$130
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Description
Recombinant Interleukin-29 (IFN-lambda) is a disulfide-linked monomer protein consisting of 178 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding murine Interleukin-29 mature chain was expressed in E. coli.
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Synonyms
IL2
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥95% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from 0.2 µm filtered solution in 130 mM NaCl, 20 mM phosphate buffer, pH 7.5.
MW
20 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Amino Acids
24–200
Biological Activity
The ED50 is determined in an anti-viral assay using human HepG2 cells infected with EMCV is typically 1-5 ng/ml.
Genbank #
Q8IU54
UniProt #
Q8IU54
Background
The IFN-lambda gene family is composed of three distinct genes: IFN-lambda1 (IL-29), IFN-lambda2 (IL- 28A), and IFN-lambda3 (IL- 28B) . IFN-lambda proteins exhibit only weak homology to IL-10, but, like IL-10, they also use the IL-10R2 chain as a component of their receptor complex. The IFN-receptor complex consists of the unique ligand-binding chain IFN- R. The IFN-λ1 gene is found exclusively in primate genomes and is 81% identical to IFN-λ2/3. IFN-λs, which are now collectively referred to as type III IFNs, exhibit several features in common with type I IFNs, such as antiviral, antiproliferative, and antitumor activities.
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