Human Glial growth factor (GGF2) Recombinant

Catalog #

90255-B

$525 *

Size: 50 µg

Qty

Bulk/Custom

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Description

Recombinant human GGF2 (Glial growth factor) is a disulfide-linked monomeric protein consisting of 315 amino acid residues, and migrates as an approximately 34 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Neuregulin-1 isoform 9 (GGF2) was expressed in E. coli.

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Synonyms

Glial growth factor 2, GGF2, neuregulin-1, NRG1, heregulin, acetylcholine receptor inducing activity, ARIA, GGF

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥95% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from a 0.2 µm filtered 10 mM phosphate buffer, pH 7.0.

34 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

51–365

Biological Activity

The ED₅₀ was determined by the dose-dependent phosphorylation of human MCF-7 cells was found to be <20 ng/ml, corresponding to a specific activity of 5 x 10⁴ Units/mg.

Genbank #

Q02297

UniProt #

Q02297

Background

Neuregulins (NDF, heregulin, GGF, ARIA, or SMDF) are EGF-like growth and differentiation factors that signal through tyrosine kinase receptors of the ErbB family. The ErbB2 and ErbB4 receptors cooperate in transmission of neuregulin-1 signals in the heart, whereas ErbB2 and ErbB3 cooperate in neural crest cells.

References

1. Marchionni MA, et al. Adv Exp Med Biol. 1999,468:283-95.
2. Dimayuga FO, et al. J Neuroimmunol. 2003 Mar,136(1-2):67-74.

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Human Glial growth factor (GGF2) Recombinant

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