Human Glia Maturation Factor beta Recombinant

Catalog #

90147-B

$205 *

Size: 10 µg

Qty

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Description

Recombinant Glia Maturation Factor is a disulfide-linked monomer protein consisting of 142 amino acid residues, and migrates as an approximately 15 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human GMF-beta mature chain was expressed in E. coli.

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Synonyms

GMF-beta, Glia Maturation Factor beta

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥98% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from 0.2 µm filtered 20 mM phosphate buffer, 130 mM NaCl solution, pH 7.5.

17 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

2–142

Genbank #

P60983

UniProt #

P60983

Background

GMF-beta is a 17- kDa brain-specific protein that was isolated from bovine brain homogenate as a substance inducing the maturation of normal neurons as well as glial cells, and at first, it was considered to be a neurotrophic factor. The amino acid sequence of GMFB is highly conserved among many species, suggesting that it plays basic roles across many species. The expression of GMF-b is largely limited to the brain, especially the glial cells and some neurons . Schwann cells of the distal segment of the transected nerve express GMF-b, and this induction of GMF-b coincides with the temporal expression of nerve growth factor receptors in the cell. This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.

References

1. Circ. Res., Aug 2006, 99: 424 - 433.
2. J. Biol. Chem., Aug 2003, 278: 33519 - 33527.
3. Int. Immunol., May 2003, 15: 557 - 564.

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Human Glia Maturation Factor beta Recombinant

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