HC Toxin
Catalog #
27209
$145
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Description
HC Toxin is a reversible, cell-permeable inhibitor of HDACs. It is a cyclic tetrapeptide first isolated from C. carbonum, a maize pathogen. It up-regulates the expression of 15-lipoxygenase-1 in colorectal cancer cells and has been shown to induce fetal hemoglobin in human primary erythroid cells.
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Product Info
Storage and Usage
Citations
Purity
≥95% by HPLC.
Format
A crystalline solid
Formula
C22H34N4O6
MW
450.5 Da
Solubility
Soluble in methanol, purged with an inert gas. Solubility in methanol is
approximately 10 mg/ml. For organic solvent-free aqueous solutions, prepare by directly
dissolving the crystalline compound in aqueous buffers.
Biological Activity
HC Toxin inhibits HDACs with an IC50 = 30 nM.
CAS Registry #
83209-65-8
References
1. Brosch, G., et al., Plant Cell. 1995; 7: 1941-1950.
2. Darkin-Rattray, SJ, et al., Proc. Natl. Acad. Sci. USA. 1996; 93(23): 13143-13147.
3. Kamitani, H., et al., Carconogenesis. 2001; 22(1): 187-191.
2. Darkin-Rattray, SJ, et al., Proc. Natl. Acad. Sci. USA. 1996; 93(23): 13143-13147.
3. Kamitani, H., et al., Carconogenesis. 2001; 22(1): 187-191.