GPX4, FLAG-Tag Recombinant
Recombinant human GPX4 (glutathione peroxidase 4), encompassing amino acids 29-198(end). This construct contains an N-terminal FLAG-tag. This recombinant protein was affinity purified.
≥90%
Aqueous buffer solution
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, and 100 µg/ml FLAG peptide
GPX4, also known as glutathione peroxidase 4, is one of the eight glutathione peroxidase family of isoenzymes. It is a monomer and uses selenium as co-factor. GXP4 works as a phospholipid hydroperoxidase in protecting cell membranes from lipid peroxidation. It uses reduced glutathione during the reduction of hydrogen peroxide, hydroperoxides and lipid peroxides. The synthesis of GXP4 is metabolically costly to cells, and it seems to be regulated by SLC7A11 (cystine/glutamate transporter)-mediated cystine uptake and activation of mTORC1 (mammalian target of rapamycin complex 1). A mice knock-out model indicated the importance of this protein in embryonic development and life span. In humans, lack of GPX4 activity results in ferroptosis and spondylometaphyseal dysplasia. Its role in ferroptosis and link to mTOR1 make studies into GXP4 of interest in the field of cancer therapy. Further studies will elucidate its role in more detail and may provide therapeutical opportunities.
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