EpCAM CHO Cell Line

Catalog #

78683

$7,150 *

Size: 2 vials

Qty

Bulk/Custom

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*US Pricing only. For international pricing, please contact your local distributor.

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Description

Recombinant clonal CHO cell line stably expressing full-length human EpCAM (NM_002354). Surface expression of EpCAM was confirmed by flow cytometry. The stable clonal cell line was selected for high levels of EpCAM expression compared to the parental CHO-K1 cell line.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

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Synonyms

EpCAM, CD326, Cell surface glycoprotein Trop-1

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Product Data Gallery

Cell surface expression of EpCAM in EpCAM CHO Cell Line.

Product Info

Storage and Usage

Citations

Host Cell Line

CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent

Supplied As

Each vial contains >1 x 10⁶ cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)

Materials Required But Not Supplied

Name	Ordering Information
Thaw Medium 3	BPS Bioscience #60186
Growth Medium 3J	BPS Bioscience #79974

Genbank #

NM_002354

UniProt #

P16422

Mycoplasma Testing

The cell line has been screened to confirm the absence of Mycoplasma species.

Background

Epithelial cell adhesion molecule (EpCAM, also known as CD90) is a known biomarker of epithelial cells that regulates cell proliferation and differentiation. It is used as an epithelial cell biomarker to detect circulating tumor cells. EpCAM belongs to the small GA₇₃₃ protein family and is a homophilic transmembrane glycoprotein involved in cell-cell adhesion and tissue plasticity. It is a single-chain membrane-spanning protein with three major domains known as EpEX, involved in epidermal growth factor receptor (EGFR) mediated signaling pathways. Due to the versatile function of EpCAM and its crosstalk with other signaling pathways in cancer, EpCAM is considered an attractive target for cancer diagnosis, prognosis, and potential therapies.

References

Liu, Y., et al. Exp Hematol Oncol 11: 97 (2022).

Storage/Stability

Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage. Contact technical support at [email protected] if the cells are not frozen in dry ice upon arrival.

Growth Media

For best results, it is highly recommended to use these validated and optimized media from BPS Bioscience. Other preparations or formulations of media may result in suboptimal performance.

Thaw Medium 3 (BPS Bioscience #60186): F-12K medium supplemented with 10% FBS, 1% Penicillin/Streptomycin.

Growth Medium 3J (BPS Bioscience #79974): F-12K medium supplemented with 10% FBS, 1% Penicillin/Streptomycin plus 5 µg/ml of Puromycin.

Applications

Screen and validate antibodies against EpCAM for drug discovery and research
Screen for compounds that regulate or inhibit EpCAM signaling in a cellular context
Perform binding assays to screen for potential EpCAM ligands

Shipping Temperature

-80°C

Notes

License Disclosure
Visit bpsbioscience.com/license for the label license and other key information about this product.

Troubleshooting Guide
Visit bpsbioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected].

Warnings

Avoid freeze/thaw cycles

Scientific Category

Cell Signaling Pathway

Regulatory Status

Research Use Only

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EpCAM CHO Cell Line

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