TPH1 & TPH2 Screening Services
Tryptophan hydroxylase 1 and 2 (Tph1/2) enzymes catalyze the monooxygentation of tryptophan to 5-hydroxytryptophan (5-HTP). Following monooxygentation, 5-HTP is decarboxylated and converted to serotonin. Through tryptophan depletion, TPH1 and TPH2 can inhibit immune system function in a manner similar to IDO1,2 and TDO . As tumor cells overexpress enzymes like Tph1/2, immune cells are deprived of essential amino acids and have impaired abi...
IDO/TDO Pathway
BPS Bioscience is a trusted provider and manufacturer of IDO pathway reagents, assay kits, cell lines and services. Cancer cells use the indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) pathways to suppress the host’s immune response in order to facilitate survival, growth, invasion, and metastasis of malignant cells. IDO enzymes and IDO-related enzymes are active in many tumors, providing a direct defense against T cell attack. I...
