Search results for: 'protac'

PROTACs ® & Protein Degradation Services BPS Bioscience is a leading product manufacturer and service provider in the PROTAC space. Using our services, we can design and conduct homogeneous proximity assays to assess the chemical adaptor function of PROTACs. Targeted protein degradation using Proteolysis Targeting Chimeras, or PROTAC®, is a new and promising therapeutic method in drug discovery. PROTACs have the ability to regulate protein degradation through targeted contro...

PROTACs and Ubiquitin-Mediated Degradation Info Sheet Join the Cutting Edge  Targeted protein degradation using Proteolysis-Targeting Chimeras, or PROTACs, is a promising new therapeutic approach, especially for currently "undruggable" targets. Download our information sheet to review the advantages of PROTACs and discover tools for PROTAC and other ubiquitination and other assay kits.

Targeted Protein Degradation Targeted protein degradation strategies have invigorated drug development, enabling therapies for targets previously deemed “undruggable.” Targeted protein degradation strategies have invigorated drug development, enabling therapies for targets previously deemed “undruggable.” Targeted protein degradation (TPD) is a cutting-edge approach in drug discovery that aims to selectively remove disease-causing prote...

Targeted Protein Degradation Approaches and Applications Introduction Traditional approaches to regulate protein activity have relied on direct protein interactions by using inhibitors or ligands. However, these target only about 10% of the known 4000 disease-linked proteins, with many being considered “undruggable” due to their quaternary structure. In recent years new strategies to target “undruggable” proteins have been developed, harnessing the power of the cells’ own protei...

Small Molecule Cancer Therapy Targets For some cancers, small molecules that disrupt, inhibit, or agonize target protein function may be the best therapeutic option. Indeed, many new targeted therapeutics are now approved together with companion diagnostics to identify patient populations most likely to benefit from the new treatment. For some cancers, small molecules that disrupt, inhibit, or agonize target protein function may be the best therapeutic...

Ubiquitination Screening & Profiling Ubiquitination is a post-translational modification in which one or more ubiquitin proteins are added to a substrate protein by a stepwise reaction requiring the sequential activity of 3 enzymes: ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). While originally described as the process that labels proteins for degradation by the proteasome, ubiquitination was later found...

Ubiquitination and CBL Introduction Ubiquitination is a process that involves the covalent binding of a 76 amino acid protein called ubiquitin to a target protein. This process is crucial for cellular homeostasis, regulating many cellular processes such as protein degradation, DNA repair, and cell signaling. Ubiquitination is a multistep process mediated by a group of enzymes known as ubiquitin ligases. Gain or loss of function of any of these enzymes can lead to impaired cellular functio...

Bioactive Proteins & Enzymes BPS Bioscience specializes in manufacturing bioactive enzymes and protein complexes, offering over 2000 protein products critical for drug discovery. We feature a large selection of epigenetic and metabolic enzymes, kinases and other cell signaling proteins, as well as cancer-related proteins and their mutants, including KRAS, PARP proteins, and immune checkpoint molecules.  Contact us to learn how our products and services can help you reach your resea...

Custom Biochemical Assay Development BPS Bioscience has the capability to develop robust biochemical assays using our portfolio of assay technologies. Our biochemical assay development services enable you to generate an appropriate assay which is suitable for screening and evaluating your target of interest. Our cross-functional team of scientists can also work closely with you to develop assays for compound library screening as well as for secondary screening support. ...

Trademarks BPS Bioscience trademarks: Chemi-Verse™  ChoosE2-Opti™ ChoosE3-Freedom™ DUB-Freedom™ Fluoro-Verse™ GroovyGreen™ HiP™ Lumi-Verse™ LysA™ Maxisorp™ ONE-Step™ PARPtrap™ QuickDetect™ Quick PCR™ RediSolution™ StemBright™ Super Western™ TCellM ™ Transfection Collection™ Trademarks of other companies referenced on this website: ADP-Glo and Kinase-Glo are registered trade...

BPS Bioscience Assay Kits At the heart of our assay kits are highly active, purified proteins. These quality proteins are then optimized with ancillary reagents and buffers to produce robust, consistent, and simple-to-use assay kits. Our kits make screening for inhibitory compounds or blocking antibodies simple and accurate. We regularly i...

Kinases Protein phosphorylation regulates almost all aspects of cell biology including cellular division, metabolism, signal transduction, and much more, a discovery that earned E. Fisher and E. Krebs the Nobel prize in Physiology in 1992. Kinases catalyze the transfer of a phosphate group from ATP to another molecule. There are over 500 kinases encoded by the human genome controlling approximately 50% of all cellular functions. Kinases are...

Emerging Therapeutic Approaches Against RAS Cancer Mutations Introduction RAS (rat sarcoma virus) proteins are small GTPases involved in signal transduction as part of the RAS/MAPK (mitogen-activated protein kinase) pathway and are involved in cell proliferation and differentiation. There are three human RAS genes: KRAS (Kristen rat sarcoma virus), HRAS (Harvey rat sarcoma virus) and NRAS (neuroblastoma rat sarcoma virus). The KRAS gene encodes two isoforms, KRAS-4B and KRAS-4A, but due t...

PARP/PARPTrap™ Screening & Profiling PARP (Poly ADP-Ribose Polymerase) proteins are a large family of 17 members that catalyze the ADP-ribosylation of proteins and DNA. PARPs are part of a network of 150 proteins involved in the DNA damage response, which constantly scan and repair DNA to maintain genome integrity. The PARP proteins are involved in a wide range of biological functions: DNA repair, chromatin remodeling, mitotic spindle assembly, regulati...

PARP Assays Poly(ADP-ribose) polymerase (PARP) proteins play a crucial role in DNA repair mechanisms within cells. These enzymes are involved in the repair of single-strand DNA breaks through the base excision repair pathway. Inhibition of PARP proteins has emerged as a promising strategy in cancer therapy, particularly in tumors with defective DNA repair mechanisms, such as those with BRCA mutations. When PARP is inhibited, it prevents the repair of single-strand breaks, leading to th...

Citations   This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.  Search By Product Name or Catalog Number Name Title 10X HAT Assay Buffer (50095...

DNA Replication & Repair Screening & Profiling DNA replication and repair are crucial processes for maintaining genetic integrity and ensuring the accurate transmission of genetic information necessary for cell division, growth, and development. Errors in replication can lead to mutations, resulting in genetic disorders and increased susceptibility to diseases like cancer. DNA repair mechanisms play a vital role in identifying and correcting damage to the ...

Bromodomain Screening & Profiling The bromodomain (BRD) family members contain an evolutionarily conserved protein fold that specifically binds acetylated lysine residues. Many bromodomain-containing proteins, such as Type A histone acetyltransferases, are chromatin remodeling enzymes. Other bromodomain-containing proteins act as transcription factors to regulate gene activity. These acetyl-lysine ‘readers’ of the histone code are important regulators of develo...