Lentiviruses for SARS-CoV-2 Research
To understand the mechanism of SARS-CoV-2 cell entry, it is essential to study how Spike proteins interact with the ACE2 receptor. However, such studies are hampered by the danger of producing and manipulating live coronavirus. A safer alternative to using live coronavirus is to use recombinant lentivirus pseudotyped with the coronavirus S protein. The Spike pseudotyped lentivirus includes a luciferase reporter, allowing the monitoring of viral entry into...
Lentiviruses
Lentiviral transduction is a powerful tool for introducing genes into cells and is used extensively for cellular engineering. It has recently made its way to the clinic with ex-vivo cell therapy applications. Lentiviruses (LV) have also been used extensively for the modeling of SARS-CoV-2 viral infection of human cells.
Lentiviral transduction is a powerful tool for introducing genes into cells and is used extensively for cellular engineering...
SARS-CoV-2 Coronavirus Variants
The COVID-19 pandemic, caused by the novel SARS-CoV-2
coronavirus , has ravaged the globe, infecting over 450 million people and causing over 6 million deaths as
of early 2022. The recent emergence of new SARS-CoV-2 variants is a severe concern, especially omicron and delta
variants, as many of these mutations occur within the Spike protein and appear to increase transmissibility and
infectivity. The graphics belo...
Coronavirus Services
Biochemical Screening
Cell-Based Services
Cell Lines /CRISPR
Protein Binding Studies/BLI
BPS Bioscience has developed innovative proteins , cell lines , lentiviruses , and assay kits , to enable a wide range of preclinical activities for investigating potential COVID-19 antiviral drugs. These kits and services aim to rapidly advance drugs into the clinic by screening for compounds that prevent the ...
Virus-Based Tools
Virus-based tools such as Lentivirus, Adeno-Associated Virus (AAV), and Vesicular Stomatitis Virus (VSV) are critical for cell engineering and the study of viral infection. We have designed a suite of ready-to-use viral reagents to address a wide span of research areas including virology (particularly Coronaviruses), immunotherapy, CAR-T therapy, CRISPR, cell signaling, and more.
Lentiviruses Ideal for pseudotyp...
Claudin-18: A Therapeutic Target in Oncology
Claudins, a family of small tetraspan proteins expressed in a tissue or cell-specific manner, are major components of the multimeric protein architecture of tight junctions, which prevent ions or small molecules from passing freely between epithelial or endothelial cells. These proteins contain four transmembrane domains mainly responsible for interacting side-to-side with neighboring proteins. Two extracellular loops regulate p...
Citations
This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.
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10X HAT Assay Buffer (50095...
Neuroscience
Neuroscience research is making strides towards solutions for CNS-related disorders.
By exploring the structure, function, and development of the central nervous system (CNS), neuroscience provides insights into the fundamental mechanisms underlying how our brains function. This knowledge is essential for advancing our comprehension of neurological disorders, mental health conditions, brain malignancies, and brain-related inj...
