Structure and Function of the Claudin Family
Introduction
Claudins (encoded by the multi-gene family CLDN) are tetraspan membrane proteins found in all epithelial and endothelial cells. They serve as crucial structural components of tight junction strands, where the membranes of two adjacent cells connect to form a barrier by self-polymerization and transcellular interactions at the apical-lateral membrane of epithelia. The tight junctions prevent molecules from passing bet...
Claudin-18: A Therapeutic Target in Oncology
Claudins, a family of small tetraspan proteins expressed in a tissue or cell-specific manner, are major components of the multimeric protein architecture of tight junctions, which prevent ions or small molecules from passing freely between epithelial or endothelial cells. These proteins contain four transmembrane domains mainly responsible for interacting side-to-side with neighboring proteins. Two extracellular loops regulate p...
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Small Molecule Cell Cytotoxicity Assays
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