Search results for: 'TCR Knockout'

Adoptive Cell Therapy Using Antigen-Specific TCRs Engineered T cell receptors provide a promising therapeutic approach to fight cancer by focusing immune cells to target specific antigens. Antigen-specific T-cell receptors (TCRs) play a crucial role in the adaptive immune response by recognizing specific antigen peptides presented by MHC molecules on the surface of infected or abnormal cells. These TCRs are typically found on the surface ...

CRISPR Services  CRISPR-Cas9 is a technique used for genome editing that is adapted from the bacteria’s antiviral immune response. Bacteria capture and store DNA fragments from invading viruses within a region of their genome, and these CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) guide sequences help detect and protect the bacteria from future infections. When the CRISPR guide sequences detect an invading virus or DNA whose sequence is complementary to the CR...

Cell-Based Assays and Expression Kits Cells can be engineered to serve as readouts for cell-based assays as a complement or alternative to biochemical assays. A variety of cell-based assay types can be used for research and development applications, including signaling pathway analysis, inhibitor/activator studies, CAR-T cell functional screening, ADCC assays, high-throughput screening systems and much more. We provide a variety of cell-based assay express...

CAR-T Cell Therapy Engineering T cells using a chimeric antigen receptor (CAR) to boost specific immune cell killing has made significant progress in the treatment of some cancer types. CAR-T cell therapy may also have potential benefits beyond cancer treatment, including treatments for infectious and chronic inflammatory diseases such as hepatitis, HIV/AIDS, lupus, and arthritis. Companies are also investigating CAR-T cell therapy in organ transplantation to eliminate the n...

CAR-T Cell Therapy Engineering T cells using a chimeric antigen receptor (CAR) to boost specific immune cell killing has made significant progress in the treatment of some cancer types. CAR-T cell therapy may also have potential benefits beyond cancer treatment, including treatments for infectious and chronic inflammatory diseases such as hepatitis, HIV/AIDS, lupus, and arthritis. Companies are also investigating CAR-T cell therapy in organ transplantation to eliminate the n...

Cell Lines and Primary Cells Cell lines are extremely useful tools for the study of protein interactions, gene activation, cell signaling, viral infection, cell-to-cell communication, and other biological processes in the context of an intact cell system rather than cell-free biochemical assays. BPS Bioscience has developed over 250 stable cell lines applicable across a wide range of research areas including immunotherapy, CAR-T cell therapy, cell signaling, metabolism, neuroscience, and mu...

Claudin-18: A Therapeutic Target in Oncology Claudins, a family of small tetraspan proteins expressed in a tissue or cell-specific manner, are major components of the multimeric protein architecture of tight junctions, which prevent ions or small molecules from passing freely between epithelial or endothelial cells. These proteins contain four transmembrane domains mainly responsible for interacting side-to-side with neighboring proteins. Two extracellular loops regulate p...

The Power of Lentiviruses in Cell Engineering Introduction The ability to manipulate nucleic acids has been a key discovery that has driven research, and ultimately clinical applications, forward. It opened the door to study the impact of mutations in cellular models, dissect pathways, generate recombinant proteins and monoclonal antibodies, and is the basis of gene and cell therapy, continuing to lead to new discoveries and cure patients every day. The methods used to ...

Lentiviruses Lentiviral transduction is a powerful tool for introducing genes into cells and is used extensively for cellular engineering. It has recently made its way to the clinic with ex-vivo cell therapy applications. Lentiviruses (LV) have also been used extensively for the modeling of SARS-CoV-2 viral infection of human cells. Lentiviral transduction is a powerful tool for introducing genes into cells and is used extensively for cellular engineering...