ADP-Ribosylation Cycle Inhibitor Mix
The ADP-Ribosylation Cycle Inhibitor Mix is a 500x cocktail of two inhibitors (AZD2281 and PDD00017273). AZD2281 (Olaparib) is a PARP inhibitor with broad pan-PARP activity, which blocks a large proportion of the ADP-ribosylation of proteins. PDD00017273 is a potent, selective poly (ADP-ribose) glycohydrolase (PARG) inhibitor that blocks PARG-mediated de-ribosylation of proteins. Used together, these two inhibitors “freeze” the state of cellular ribosylation at the time the mix is applied to the cells. This product is designed to supplement a cell lysis buffer of choice to prevent post-lysis changes in the ADP-ribosylation status of extracted proteins.
5 mM AZD2281 (Olaparib) (BPS Bioscience #27003) and 5 mM PDD00017273 in 100% DMSO (Dimethyl sulfoxide).
Olaparib: C24H23FN4O3; PDD00017273: C23H26N6O4S
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