Human Tissue Plasminogen Activator
Catalog #
90248-B
$205
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Synonyms
PLAT, tPA, Tissue Plasminogen Activator, Reteplase
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
CHO cells
Purity
≥98% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from a 0.2 µm filtered 1 mg/ml solution containing 0.2 M L-arginine, 0.1 M phosphoric acid.
MW
60 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Amino Acids
36–562
Biological Activity
The activity was determined to be 6 x 105 IU/mg.
UniProt #
P00750
Background
Tissue plasminogen Activator (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots. Specifically, it is a serine protease (EC 3.4.21.68) found on endothelial cells lining the blood vessels. It catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for clot breakdown.
References
1. Ortolano S, Spuch C. Recent Pat Endocr Metab Immune Drug Discov. 2013 Jan,7(1):65-76.
2. Eissa A, et al. J Clin Pharm Ther. 2012 Dec,37(6):620-9.
3. Adibhatla RM, Hatcher JF. CNS Neurol Disord Drug Targets. 2008 Jun,7(3):243-53.
2. Eissa A, et al. J Clin Pharm Ther. 2012 Dec,37(6):620-9.
3. Adibhatla RM, Hatcher JF. CNS Neurol Disord Drug Targets. 2008 Jun,7(3):243-53.
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