Human HCC-4(CCL16) Recombinant

Catalog #

90154-B

$205 *

Size: 25 µg

Qty

Bulk/Custom

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Description

Recombinant LEC/CCL16 is a disulfide-linked monomeric protein consisting of 98 amino acid residues and migrates as an approximately 11 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human LEC (CCL16) mature chain was expressed in E. coli.

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Synonyms

CCL16, LEC, HCC-4, Lymphocyte And Monocyte Chemoattractant, LCC-1, NCC-4, CKb12, Liver CC Chemokine-1, Monotactin-1, MTN1

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥98% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from 0.2 µm filtered solution in 100 mM NaCl, 20 mM phosphate buffer, pH 7.5.

11 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

24–120

Biological Activity

Determined by its ability to chemoattract human monocytes using a concentration range of 2.0-40.0 ng/ml.

Genbank #

O15467

UniProt #

O15467

Background

CCL16, also known as liver- expressed chemokine or NCC-4 or lymphocyte and monocyte chemoattractant or HCC-4, is a CC chemokine that specifically attracts lymphocytes, dendritic cells, and monocytes, it increases their adhesive properties and has myelosuppressive activity. CCL16 is constitutively expressed in liver and is increased by interleukin 10 (IL-10) in activated monocytes. CCL16 is present in human plasma suggesting that it may be active outside hepatic tissue. CCR1, CCR2, CCR5, and CCR8 are the functional receptors of this chemokine.

References

1. J. Leukoc. Biol., Jan 2004, 75: 135.
2. Blood, Jan 2004, 103: 40 - 49.

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Human HCC-4(CCL16) Recombinant

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