Human HCC-2(CCL15) Recombinant
Catalog #
90153-B
$205
*
●
●
Purchase
Description
Recombinant HCC-2 is a disulfide-linked monomeric protein consisting of 92 amino acid residues and migrates as an approximately 10 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human HCC-2 (CCL15) mature chain was expressed in E. coli.
●
Synonyms
HCC-2, CCL15
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥98% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from 0.2 µm filtered solution in 100 mM NaCl, 20 mM phosphate buffer, pH 7.5.
MW
10 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Amino Acids
22–113
Biological Activity
Determined by its ability to chemoattract human monocytes using a concentration range of 2.0-40.0 ng/ml.
Genbank #
Q16663
UniProt #
Q16663
Background
CCL15 is a human chemokine which acts predominantly on chemokine receptor CCR1 and to a lesser degree on CCR3. It is a potent chemoattractant for monocytes and lymphocytes in vitro and, after immunoprecipitation, CCL15 induces recruitment neutrophils, monocytes, and lymphocytes into mouse peritoneum. CCL15 is constitutively expressed in the gut and in the liver and was identified to circulate in human plasma. The N-terminus of CCL15 was found to be important to exert its full biological activity. HCC-2 shares significant sequence homology with CKb8 and the murine chemokines C10, CCF18/MRP-2, and macrophage inflammatory protein 1g (MIP-1g), which all contain six instead of four conserved cysteines.
References
J. Leukoc. Biol., Sep 2001, 70: 357.
Powered by Bioz
6405 Mira Mesa Blvd. Suite 100
San Diego, CA 92121
858-202-1401
San Diego, CA 92121
858-202-1401
Products are for Research Use Only
COMPANY
Copyright © 2024
BPS Bioscience, Inc.
All rights reserved.
Diagrams on this website are created with BioRender.com.