LC-2
Catalog #
82058
$525
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Description
LC-2 is a von Hippel-Lindau-based PROTAC which can degrade endogenous KRAS G12C. It covalently binds KRAS G12C with a MARTX849 warhead and recruits the E3 ligase VHL which degrades the KRAS G12C and suppresses MAPK signaling in homozygous and heterozygous KRAS G12C cell lines.
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Product Info
Storage and Usage
Citations
Format
Solid
Formula
C59H71ClFN11O7S
MW
1132.8 Da
CAS Registry #
2502156-03-6