CD7 CHO Cell Line (Medium or High Expression)

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Catalog #

78324

As low as $7,150 *

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Description

Recombinant CD7 CHO-K1 cell lines expressing full-length human CD7 receptor (accession number: NM_006137.6). Surface expression of human CD7 was confirmed by flow cytometry. Each stable clonal cell line was selected for high or medium levels of CD7 expression to mimic different stages of cancer target cells with various CD7 expression levels.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

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Synonyms

T-cell antigen CD7, GP40, T-cell leukemia antigen, T-cell surface antigen Leu-9, TP41, CD_antigen: CD7, Tp40, LEU-9

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Product Data Gallery

Flow cytometry analysis of cell surface expression of human CD7 in CHO-K1 cells

Product Info

Storage and Usage

Citations

Host Cell Line

CHO-K1 Chinese Hamster Ovary, epithelial-like cells, adherent

Species

Human

Supplied As

Each vial contains 2 x 10⁶ cells in 1 ml of 10% DMSO

Materials Required But Not Supplied

Materials Required for Cell Culture

Name	Ordering Information
Thaw Medium 3	BPS Bioscience #60186
Growth Medium 3B	BPS Bioscience #79529

Formulation

For best results, it is highly recommended to use these validated and optimized media from BPS Bioscience. Other preparations or formulations of media may result in suboptimal performance.

Media Required for Cell Culture
Thaw Medium 3 (BPS Bioscience #60186):
F-12K Medium (Kaighn's Modification of Ham's F-12 Medium) supplemented with 10% FBS, 1% Penicillin/Streptomycin.

Growth Medium 3B (BPS Bioscience #79529):
F-12K Medium (Kaighn's Modification of Ham's F-12 Medium) supplemented with 10% FBS, 1% Penicillin/Streptomycin plus 500 μg/ml of Hygromycin B

UniProt #

P09564

Mycoplasma Testing

The cell line has been screened to confirm the absence of Mycoplasma species.

Background

The CD7 antigen is a single-domain immunoglobulin superfamily molecule. It plays an essential role in T-cell interactions and T-cell/B-cell interaction during early lymphoid development. CD7 is highly expressed on malignant immature T cells and is generally absent on malignant mature T cells, such as CD4+ Sezary leukemia and HTLV-1+ adult T-cell leukemia cells. Interestingly, loss of CD7 antigen is observed in the subset of CD4⁺ memory T cells in some pathological conditions. Several studies indicate that the number of CD4⁺ CD7^- T cells increase in chronic inflammation and various T-cell malignancies. CD7 is expressed in 95% of T-cell acute lymphoblastic leukemia (T-ALL) cases, which makes it an ideal target for T-ALL treatment.

Storage/Stability

Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Instructions for Use

See assay protocol for detailed instructions.

Applications

• Screen for compound activity on antibody-mediated CD7 signaling for immunotherapy research and drug discovery.
• Characterize CD7 antibodies and ligands.

Shipping Temperature

-80°C

Notes

License Disclosure
Visit bpsbioscience.com/license for the label license and other key information about this product.

Troubleshooting Guide
Visit bpsbioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected].

Warnings

Avoid freeze/thaw cycles.

Scientific Category

Immunotherapy

Regulatory Status

Research Use Only