CD5– CHO K1 Recombinant Cell Line (High, Medium, or Low Expression)
Recombinant CD5-CHO K1 cell line stably expressing a full-length human CD5 receptor (accession number: NM_014207.3). Surface expression of hCD5 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of hCD5 expression (High, Medium and Low) to mimic different stages of cancer target cells with various CD5 expression levels.
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Materials Required for Cell Culture
| Name | Ordering Information |
| Thaw Medium 3 | BPS Bioscience #60186 |
| Growth Medium 3B | BPS Bioscience #79529 |
For best results, it is highly recommended to use these validated and optimized media from BPS Bioscience. Other preparations or formulations of media may result in suboptimal performance.
Thaw Medium 3 (BPS Bioscience #60186): F-12K Medium supplemented with 10% FBS, 1% Penicillin/Streptomycin
Growth Medium 3B (BPS Bioscience #79529): F-12K Medium supplemented with 10% FBS, 1% Penicillin/Streptomycin plus 500 μg/ml of Hygromycin B
The cell line has been screened to confirm the absence of Mycoplasma species.
CD5 is a type-1 transmembrane glycoprotein with an extracellular region composed of three scavenger receptor, cysteine-rich domains. This lymphocytic-specific scavenger receptor functions at the interphase of the innate and adaptive immune responses. It is involved in: (i) microbial-associated pattern recognition; and (ii) modulation of intracellular signals mediated by antigen-specific receptor present in T and B cells. CD5 is expressed by all T cells and some B cell subsets (B1a and Breg or B10). T cells usually express higher levels of CD5 than B cells, and CD5 is upregulated in T cells upon strong activation. CD5 is a signaling co-receptor, associated with the antigen-specific receptor complex of T and B cells, and down-modulates the activation/differentiation signals delivered upon specific antigen recognition. The signaling pathway used by CD5 is only partially known.
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