CRISPR-Based Synergistic Activation Mediator (SAM)
Introduction
Cas9 ( Streptococcus pyogenes CRISPR-associated protein 9) is a sequence-specific prokaryotic endonuclease that is recruited to the DNA by a single guide RNA (sgRNA) and introduces a double stranded break into the DNA. This double stranded break is usually repaired through Non-Homologous End Joining (NHEJ) in mammalian cells (1) . The target DNA sequence requires only 23 bp (base pairs) in length and sho...
CRISPR Products & Services
Cells
Lentiviruses
Proteins
Services
CRISPR-Cas9 is a tool used for genome editing that has been adapted from the bacteria’s innate immune response. Bacteria capture and store DNA fragments from invading viruses or DNA within a region of their genome termed the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) array. This region is continually transcribed, producing short CRISPR RNA (cr...
CRISPR Services
CRISPR-Cas9 is a technique used for genome editing that is adapted from the bacteria’s antiviral immune response. Bacteria capture and store DNA fragments from invading viruses within a region of their genome, and these CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) guide sequences help detect and protect the bacteria from future infections. When the CRISPR guide sequences detect an invading virus or DNA whose sequence is complementary to the CR...
Cell Lines and Primary Cells
Cell lines are extremely useful tools for the study of protein interactions, gene activation, cell signaling, viral infection, cell-to-cell communication, and other biological processes in the context of an intact cell system rather than cell-free biochemical assays. BPS Bioscience has developed over 250 stable cell lines applicable across a wide range of research areas including immunotherapy, CAR-T cell therapy, cell signaling, metabolism, neuroscience, and mu...
