Cell Lysis Buffers
Selecting the right cell lysis buffer is a critical step in many research applications across various scientific disciplines, ranging from molecular biology to cell biology and biochemistry. The choice of cell lysis buffer can significantly impact the quality and reliability of experimental results, making it a fundamental consideration for researchers. This importance stems from several key factors.
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Support Products & Consumables
Off-the-Shelf Solutions and Kits for Cell and Protein Analysis
In scientific experimentation, even basic components such as buffers and reagents can have a significant influence on the integrity of experimental outcomes. Accurate preparation and proper selection of buffers are crucial for achieving consistent and reliable results. For instance, in processes like cell lysis, the choice of the appropriate buffer can ...
HDAC/Sirtuin Screening & Profiling
Histone deacetylases (HDACs) are negative regulators of gene transcription due to their ability to tightly compact heterochromatin by removing acetyl groups from histone tails. Thus, they are considered important targets for anti-cancer therapeutics due to their involvement in cell cycle regulation, cell proliferation, and apoptosis, and overall gene expression. Similarly, the Sirtuin family of deacetylases are targets ac...
Citations
This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.
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10X HAT Assay Buffer (50095...
AAV Tools
Graham Beards’ Own work CC BY-SA 4.0
Adeno-Associated Virus (AAV) is a small dependoparvovirus which was initially discovered as a contaminant in adenovirus preparations. AAVs are non-enveloped and consist of an icosahedral capsid containing a short, single-stranded DNA genome flanked by two Inverted Terminal Repeat sequences (ITRs).
AAVs are replication-defective, non-pathogenic, and h...
Cellular PARylation: From Inquiry to Insight in Drug Discovery
Summary
Inhibitors of poly (ADP-ribose) polymerases (PARPs) have been game-changing in cancer therapy, demonstrating the potential efficacy of synthetic lethal drugs targeting complementary pathways within the DNA damage response network. However, the evaluation of poly-ADP-ribosylation in intact cells is difficult, slowing the development of candidate drugs. BPS Bioscience’s LysA™ Universal PARylation Assay Kit quantifies...
Gene & Cell Therapy
Gene and cell therapies are paving the way for innovative treatments that can offer new hope for patients with previously untreatable diseases.
Gene therapy and cell therapy are cutting-edge medical approaches aimed at revolutionizing healthcare. Gene therapy involves the manipulation and introduction of genetic material into a patient's cells to correct genetic disorders or enhance therapeutic effects. This can be achieved by ...
PARP Assays
Poly(ADP-ribose) polymerase (PARP) proteins play a crucial role in DNA repair mechanisms within cells. These enzymes are involved in the repair of single-strand DNA breaks through the base excision repair pathway. Inhibition of PARP proteins has emerged as a promising strategy in cancer therapy, particularly in tumors with defective DNA repair mechanisms, such as those with BRCA mutations. When PARP is inhibited, it prevents the repair of single-strand breaks, leading to th...
Custom AAV Services
Adeno-Associated Viruses (AAV) are useful for gene therapy due to their gene transfer efficiency and safety. Inside the cell, AAVs are episomal and result in the sustained expression of a gene of interest for up to 6 months in non-dividing cells. Our off-the-shelf AAVs can be used in a Biosafety Level 1 (BSL-1) facility.
BPS Bioscience is developing a portfolio of AAV products to support your research needs. Our custom s...
CAR T-Cell Therapy
Overview
CAR-T is a cross of immunotherapy, gene therapy, and cellular therapy. Many successful immunotherapies are based on checkpoint inhibitors that block the mechanisms tumor cells use to hide from T cells. CAR-T immunotherapies go one step further by engineering T cells to enhance the immune response against a specific tumor antigen. CAR-T is a promising approach for cancer and other diseases, especially severe cancers that do not respond well to othe...
Frequently Asked Questions
BPS Bioscience is here to answer your questions and provide project guidance. On the following pages, we outline some of the most frequently asked questions separated by product type. If your question is not answered through these resources, please contact us today and we are happy to assist.
Proteins
Cell Lines
Assay Kits ...
