Protease Screening & Profiling
Proteases are catalytic enzymes found in all forms of life, including viruses, that regulate a wide range of vital physiological processes. In animals, they are critical for digestion of food, lysosome and proteasome degradation, apoptosis, blood coagulation, cell cycle regulation, cell signaling, and more. The dysregulation of protease activity can lead to pathologies such as arthritis and inflammatory diseases, cardiovascul...
Proteases as Targets for SARS-CoV-2 Treatment
Researchers have shown that proteases are actively used by SARS-CoV-2 for it’s entry and replication into human cells. To support research on this topic, BPS Bioscience provides a range of screening kits to identify inhibitory compounds directed against these human and viral proteases.
SARS-CoV-2’s mechanism of entry and replication into human cells is now well known and described by the scientific community. The penetration steps can be d...
SARS-CoV-2 Coronavirus & COVID-19
There are seven known human coronaviruses , including the novel SARS-CoV-2. Four of these strains cause only mild respiratory symptoms; however, coronaviruses became notorious after outbreaks of Severe Acute Respiratory Syndrome (SARS) in 2002 and Middle East Respiratory Syndrome (MERS) in 2012. The SARS-CoV-2 (2019-nCoV) coronavirus, first identified in late 2019, causes severe pneumonia and respiratory infection (COVID-19).
The S...
