Mechanism of JAK-STAT Signaling in Cancer
Cell Signaling Pathways
Understanding cell to cell communication through cytokines and other secreted factors is at the center of daily life for countless pharmaceutical researchers. This is because cytokine-based communication is central to normal development and is often a dysfunctional step in cancer and autoimmune diseases ( 1, 2 ). It is also of increasing importance because cytokine release syndrome is a leading caus...
Bioactive Proteins & Enzymes
BPS Bioscience specializes in manufacturing bioactive enzymes and protein complexes, offering over 2000 protein products critical for drug discovery. We feature a large selection of epigenetic and metabolic enzymes, kinases and other cell signaling proteins, as well as cancer-related proteins and their mutants, including KRAS, PARP proteins, and immune checkpoint molecules. Contact us to learn how our products and services can help you reach your resea...
Kinases
Protein phosphorylation regulates almost all aspects of cell biology including cellular division, metabolism, signal transduction, and much more, a discovery that earned E. Fisher and E. Krebs the Nobel prize in Physiology in 1992.
Kinases catalyze the transfer of a phosphate group from ATP to another molecule. There are over 500 kinases encoded by the human genome controlling approximately 50% of all cellular functions. Kinases are...
