Cell Signaling Pathway Screening & Profiling
In order to determine effectors of cell signaling pathways in the context of intact functioning cells, cell-based reporter assays are an ideal option. Using luciferase reporters downstream of a pathway-specific promoter response element, signaling activity can be conveniently measured by the output of luciferase activity. The system can be applied across a wide variety of cell types and signaling pathways and allows for ...
OX40 Signaling and Its Implications for Immunotherapy
Introduction
Immune checkpoint OX40, also known as CD134 or TNFRSF4, is a co-stimulatory molecule belonging to the tumor necrosis factor receptor (TNFR) superfamily. Its significance in regulating immune responses has garnered substantial attention in the field of immunotherapy. OX40 signaling plays a crucial role in modulating T cell activation, differentiation, and survival, thereby influencing the outcome of immune responses agains...
