The Role of ADAR1 in Biology and Disease
Adenosine deaminases acting on RNA (ADAR) proteins catalyze the post-transcriptional modification of adenosine to inosine (A-to-I) on double-stranded RNA (dsRNA) molecules. The ADAR proteins edit A to I non-selectively in extended perfect double-stranded RNA duplexes, an activity that is of ancient origin and highly conserved. ADAR1 functions as a major RNA editor, resulting in the differential regulation of RNA processing by other RNA-binding protein...
Conferences & Events
Development of a Cell-Based Reporter Assay for Measuring ADAR1 Editing Activity for Drug Discovery and Cell Biology Research
May 21, 2024 (8:00 AM PT, 11 AM ET)
Adenosine Deaminase Acting on RNA (ADAR) enzymes perform adenosine to inosine base editing in RNA, particularly targeting adenosines located within a specific double-stranded stem-loop motif. ADAR1 plays important roles in inflammation, autoimmune diseases, and cancer, and represents ...
