Ubiquitination

Ubiquitin is an 8.5 kDa protein that is expressed in almost all tissues, hence the name. Ubiquitination is a post-translational modification in which one or more ubiquitin proteins is added to a substrate protein by a reaction that is carried out in three main steps; activation, conjugation, and ligation. Addition requires the sequential action of 3 enzymes, ubiquitin activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). Ubiquitination was originally described as the process that labels proteins for degradation by the proteasome, but was later found to have a number of distinct functions such as altered protein localization, modulation of protein-protein interaction, and activation or inactivation of target proteins. In addition to the highly studied proteosomal degradation pathway, ubiquitin modifications have been linked to the regulation of a number of other important cellular processes, including inflammation, response to stress or viral infections, DNA repair, and stem cell differentiation.

Many proteins regulated by ubiquitin modification control cellular processes that are essential for tumorigenesis and tumor growth, including cell cycle progression, apoptosis, and receptor trafficking and down-regulation. Recent years have seen significant progress in our understanding of the molecular basis of ubiquitin modifications in cancer progression and it has therefore become an attractive drug target.

BPS provides a number of active ubiquitin enzymes in addition to inhibitors and activators to give researchers the tools necessary to continue to advance our understanding of this important target.

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Catalog#SizeProduct NamePrice
80323 100 µg UbcH13 (UBE2N), His-tag
$250
80315 100 µg UbcH5a (UBE2D1), His-tag
$250
80314 100 µg UbcH5b, His-Tag (Human)
$250
80313 100 µg UbcH5c, His-Tag (Human)
$250
80316 100 µg UbcH6 (UBE2E1), His-tag
$250
80317 100 µg UbcH7, His-tag (E. coli-derived)
$290
80318 50 µg UbcH7, His-tag (Sf9-derived)
$290
80301 100 µg UBE1 (UBA1), FLAG-tag
$305
79368 20 µg UBE2A, His-Tag
$310
79369 20 µg UBE2C, His-Tag
$310
79370 20 µg UBE2D2, His-Tag
$310
80302 20 µg UBE3A, His-FLAG-tags
$370
81150 50 µg Ubiquitin AMC
$350
11236 50 µg Ubiquitin, His-Avi-Tag, Biotin Labeled
$250
79293 2 mg Ubiquitin, His-Tag
$100
81151 50 µg Ubiquitin-Rhodamine
$370
81099 25 µg UCH-L5, SUMO-His-tags
$410
80351 100 µg UCHL1 (PGP9.5), His-tag
$365
80353 100 µg UCHL3, His-tag
$365
80325 100 µg UEV1A (UBE2V1), FLAG-tag
$290
80411 20 µg UFL1, GST-tag
$370
55001 50 µg UHRF1, His-FLAG-tags
$440
80360 50 µg USP10, FLAG-tag
$425
80364 50 µg USP14, FLAG-tag
$425
81100 25 µg USP15, SUMO-His-tags
$350

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