Ubiquitination

Ubiquitin is an 8.5 kDa protein that is expressed in almost all tissues, hence the name. Ubiquitination is a post-translational modification in which one or more ubiquitin proteins is added to a substrate protein by a reaction that is carried out in three main steps; activation, conjugation, and ligation. Addition requires the sequential action of 3 enzymes, ubiquitin activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). Ubiquitination was originally described as the process that labels proteins for degradation by the proteasome, but was later found to have a number of distinct functions such as altered protein localization, modulation of protein-protein interaction, and activation or inactivation of target proteins. In addition to the highly studied proteosomal degradation pathway, ubiquitin modifications have been linked to the regulation of a number of other important cellular processes, including inflammation, response to stress or viral infections, DNA repair, and stem cell differentiation.

Many proteins regulated by ubiquitin modification control cellular processes that are essential for tumorigenesis and tumor growth, including cell cycle progression, apoptosis, and receptor trafficking and down-regulation. Recent years have seen significant progress in our understanding of the molecular basis of ubiquitin modifications in cancer progression and it has therefore become an attractive drug target.

BPS provides a number of active ubiquitin enzymes in addition to inhibitors and activators to give researchers the tools necessary to continue to advance our understanding of this important target.

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Catalog#SizeProduct NamePrice
81085 25 µg JosD1, His-tag
$410
81086 25 µg JosD2, His-tag
$410
80410 20 µg KCTD13, GST-tag
$370
27705 500 ug Lactacystin
$350
27706-2 50 mg LDN-57444
$445
27706-1 10 mg LDN-57444
$175
27707 25 mg MDBN
$250
80751 20 µg MDM2, GST-tag
$375
27708 1 mg MLN-4924
$305
81052 25 µg MuRF1, SUMO-His-tags
$355
81053 25 µg MuRF2, SUMO-tag
$355
81054 25 µg MuRF3, SUMO-His-tags
$355
80404 20 µg NEDD4, FLAG-tag
$385
81087 50 µg NEDD8 E1, His-tag
$295
27709-1 10 mg NSC-632839
$180
27709-2 50 mg NSC-632839
$310
27710 10 mg NSC-66811
$230
27765-2 25 mg NSC697923
$180
27765-1 10 mg NSC697923
$140
81088 25 µg Otub1, His-tag
$315
81089 25 µg Otub2, His-tag
$350
80407 50 µg OTUD6B, His-FLAG-tags
$425
27767-1 10 mg P005091
$145
27767-2 50 mg P005091
$330
27712-1 10 mg P22077
$235

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