Ubiquitination

Ubiquitination



Ubiquitination plays a crucial role in maintaining cellular homeostasis, regulating various cellular processes such as protein turnover, DNA repair, cell cycle progression, and signal transduction.

Ubiquitination



Ubiquitination plays a crucial role in maintaining cellular homeostasis, regulating various cellular processes such as protein turnover, DNA repair, cell cycle progression, and signal transduction.

Ubiquitination is a cellular process in which ubiquitin, a small regulatory protein, is attached to target proteins, typically marking them for degradation by the proteasome, a protein complex responsible for breaking down unneeded or damaged proteins. This process involves a series of enzymatic steps, including activation by E1 enzymes, conjugation by E2 enzymes, and ligation by E3 ligases, which transfer ubiquitin to the substrate protein. Ubiquitination was originally described as the process that labels proteins for degradation by the proteasome but was later found to have a number of distinct functions such as altering protein localization, modulation of protein-protein interaction, and activation or inactivation of target proteins. In addition to the highly studied proteasomal degradation pathway, ubiquitin modifications have been linked to the regulation of multiple other important cellular processes, including inflammation, response to stress or viral infections, DNA repair, and stem cell differentiation.

Ubiquitination Diagram

Many proteins regulated by ubiquitin modification control cellular processes that are essential for tumorigenesis and tumor growth, including cell cycle progression, apoptosis, and receptor trafficking and down-regulation. Recent years have seen significant progress in our understanding of the molecular basis of ubiquitin modifications in cancer progression and it has therefore become an attractive drug target. Furthermore, the proteasomal degradation pathway is now being utilized to specifically target disease-causing proteins, previously deemed “undruggable”, using PROTACs and molecular glues.

Innovative solutions for ubiquitination-related drug discovery research

Purified Bioactive Recombinant Proteins

Assay Kits

Assay Kits
  • Features kits designed for screening small molecule inhibitors of ubiquitination and deubiquitination, including intrachain kits to detect polyubiquitination.
  • PROTAC and molecular glue optimization kits
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Deubiquitination Products

Deubiquitination
  • Features bioactive deubiquitinase enzymes and inhibitor screening assay kits
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