T Cells Research Products

T lymphocytes are white blood cells involved in the adaptive immune response. They are activated by infected, foreign, or cancerous cells. T cells help activate other immune cells and regulate the immune system, while developing immunological memory to enable a rapid response upon future exposure to the same pathogen.

T lymphocytes are white blood cells involved in the adaptive immune response. They are activated by infected, foreign, or cancerous cells. T cells help activate other immune cells and regulate the immune system, while developing immunological memory to enable a rapid response upon future exposure to the same pathogen.

The therapeutic applications of T cells hold great promise for improving the treatment of various diseases by harnessing and manipulating the power of the body's immune system. T cells have been exploited as therapeutic agents in several disease applications, particularly for cancer treatment and autoimmune disease management.

Some of the key therapeutic applications of T cells include adoptive cell therapy using T cells engineered to express a chimeric antigen receptor (CAR) or a TCR (T cell receptor) specifically directed against a cancer antigen, for the treatment of cancer or auto-immune diseases. Another approach is to use checkpoint inhibitors, which help unleash T cell responses by blocking the inhibitory signals that cancer cells use to evade the immune system. Multi-specific T cell engagers, which bind simultaneously to a specific cell surface protein on tumor cells and to a T cell-specific protein such as CD3, are being assessed for their capacity to recruit T cells to the tumor and activate and immune response.

T cells can also be utilized for non-cancer applications as well. Regulatory T cells (Tregs), which suppress excessive immune responses, have been explored for treating auto-immune or inflammation-related diseases. Furthermore, engineered T cells that can recognize and eliminate virus-infected cells have shown potential in treating persistent viral infections like HIV, cytomegalovirus (CMV), and hepatitis B and C.

T cell lymphocytes are mainly composed of two T cell subpopulations, αβ and γδ, which are distinguished by the expression of an αβ or a γδ TCR, respectively. The αβ cells are the predominant T cell subset in the circulation and recognize antigens presented by MHC (major histocompatibility complex) molecules. The γδ-T cell subset is much less abundant and recognize antigens independently of MHC presentation. Both can target and eliminate infected or abnormal cells. However, γδ-T cells injected into patients have a lower risk of causing graft-versus-host disease compared to αβ-T cells, while retaining cytotoxicity against a wide range of tumor types.

Our Complete Suite of Tools Support your T Cell Workflow

Once T cell populations of interest have been enriched and expanded, they can be used for downstream applications such as generation of CAR-T or TCR-T cells, measurement of cell activation, cytotoxicity analysis in co-culture assays, determination of cytokine release, and more.

Primary Human T cells, Frozen

• Engineered CAR T cells directed to CD19, CD20, BCMA, and more, are reliable positive controls
• Expanded human CD4+, CD8+, or γδ T cells are ideal starter cells for research
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T Cell Expansion and Isolation Kits

• Human T Cell Isolation kits and γδ T Cell Expansion kits simplify T cell research
• Buffers, optimized media, and cytokines
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Knockout Cell Lines

• B2M, B2M/CIITA, TCR, and TCR/B2M knockout cells for introducing new TCR constructs
• Without or with NFAT luciferase reporter for activation studies
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Cell-Based Cytotoxicity Assay Kits

• PBMC bioassays for assessing the efficacy of immune engagers
• ADCC bioassay effector cells for measuring antibody-mediated T cell activation
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Antibodies

• Neutralizing or agonistic antibodies target immune checkpoints
• Human T cell Activation Reagent
• Labeled antibodies against T cell markers
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Multi-specific T Cell Engagers

• Validated bispecific and tri-specific molecules make trustworthy internal controls
• Find bi- and tri-specific against CD3 and CD19, BCMA, CD20, and many more
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Cell Lines for T Cell Research

• TCR activator cell lines
• Immune checkpoint molecule-expressing cell lines
• Reporter cells for co-culture assays streamline cytotoxicity experiments
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Custom Services

• CAR T & TCR T cell development services accelerate your research
• Custom lentivirus or AAV production
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