Bromodomain Screening and Profiling

Accelerate your drug discovery program with Bromodomain Screening and Profiling Services from BPS Bioscience, Inc. Trust us to provide you with high quality data with fast turnaround time. Our team of experts along with our broad services portfolio makes it easy to:

  • Screen for inhibitors/targets using our panel of >20 assays
  • Select from IC50 determination and single point concentrations
  • Receive data within days of compound submission
  • Perform follow-up studies using the same proteins manufactured in-house
  • Get questions answered or project guidance in a time-efficient manner

List of Biochemical Assays:

ATAD2A BRD2 (BD1 + BD2) BRD9 SMARCA2
ATAD2B BRD3 (BD1) BRDT (BD1) TAF1 (BD2)
BAZ2B BRD3 (BD2) BRDT (BD1+BD2) TAF1 (BD1 + BD2)
BPTF/FALZ BRD3 (BD1 + BD2) BRG1 TAF1L (BD2)
BRD1 BRD4 (BD1) BRPF3 TAF1L (BD1 + BD2)
BRD2 (BD1) BRD4 (BD2) CECR2 TRIM24
BRD2 (BD2) BRD4 (BD1 + BD2) CREBBP WDR9/BRWD1

Background:

The bromodomain family contains an evolutionarily conserved protein fold that specifically binds acetylated lysine residues. This recognition facilitates function by promoting protein-protein interaction. Many bromodomain-containing proteins, such as Type A histone acetyltransferases, are chromatin remodeling enzymes. Other bromodomain-containing proteins act as transcription factors to regulate gene activity.

The human genome encodes more than 50 bromodomain-containing proteins, which can be subdivided into 8 families. These ‘readers’ of the histone code are important regulators of development and normal biological processes. Several key BRD-containing proteins include Brd2 and Brd3, which are associated with MHC recognition, inflammation, and immune response, and Brd4 (also called MCAP), which associates with chromosomes during mitosis. All three BRD proteins have been identified as potential cancer targets. Although a number of bromodomain inhibitors have been developed, including the widely used JQ1, their efficacy in disease states have been limited, highlighting the need for further development of bromodomain inhibitors.

BPS Bioscience has one of the largest libraries of bromodomian-containing proteins. Our portfolio includes highly purified proteinsassay kits, and inhibitors & activators. As with all of our products, we perform rigorous QC testing of our bromodomain products to ensure that we are producing only high-quality, consistent products.

Contact us today for more information about our Bromodomain Screening and Profiling Services.

Related Technologies:

  • AlphaScreen ®
  • TR-FRET

Not quite what you’re looking for? Our Custom Assay Development Services allow for flexibility to meet your specific research needs