PTPμ (PTPRM), GST-tag Recombinant

Catalog #
30053
$325 *
Size: 50 µg
Qty
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Description

PTPμ (mu) (protein tyrosine phosphatase mu, also known as RPTPµ), catalytic domain, (a.a. 896-1175), (GenBank Accession No. NM_001105244) with N-terminal GST tag, MW=56.2 kDa, expressed in an E. coli expression system.

Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity

≥81%

Format
Aqueous buffer solution
Formulation
25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione
MW
56.2 kDa
Amino Acids
896–1175
Specific Activity
60 U/µg
Genbank #
NM_001105244
UniProt #
P28827
Tag(s)
N-terminal GST-tag
Background
PTPRM is a member of the protein tyrosine phosphatase family and can participate in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRM has been shown to mediate cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. PTPRM can interact with scaffolding protein RACK1/GNB2L1 and this interaction may be necessary for downstream signaling in response to cell-cell adhesion. PTPRM has been shown to be expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity.
References
1. S. Brady-Kalnay, et al., J. Cell Biol 1995, 130: 977.
2. T. Mourton, et al., J. Biol. Chem. 2002, 276:14896.